Cloud computing infrastructure is becoming ubiquitous worldwide. With the rapid growth of digitization and IoT devices, the need of large-scale Cloud infrastructure keeps increasing, which presents greater challenges to its management and operational efficiency. At Alibaba Cloud Intelligence, we focus on using data and the very best techniques that Cloud enables, such as AI algorithms, to manage the Cloud infrastructure itself in an autonomous fashion. In this talk, we give an overview of the top issues Cloud infrastructure operation is facing. Then we share some recent progress on specific topics such as fast datacenter anomaly detection, hardware failure prediction, cluster-level self-healing and so on.